Neoplasm and Not Elsewhere Specified

This is due to the fact that, by blocking Na + channels in the phase of the plateau (phase, lidocaine shortens this phase, phase 3 (repolarization) starts earlier 3. Contraindicated in glaucoma, prostatic hypertrophy, atrioventricular block II-III degree. It is used for ventricular and supraventricular tachyarrhythmias (particularly when fibrilloflutter for sinus Chronic Venous Congestion of atrial contractions), as well as beats. In connection with the low bioavailability of the drug is administered intravenously. With prolonged use of procainamide may hemolytic anemia, leukopenia, agranulocytosis, the development of syndrome of systemic lupus erythematosus (initial symptoms - skin here arthralgia). Side effects of procainamide: hypotension (associated with ganglioblokiruyuschimi properties procainamide), here of face, neck, disturbances atrioventricular conduction, nausea, vomiting, headache, insomnia. From radrenoblokatorov as antiarrhythmic use of propranolol, metoprolol, atenolol, and others Blockers, blocking radrenoretseptor, eliminate the stimulatory effect of sympathetic innervation of the heart and in connection with this decline: sinoatrial automaticity node automatism and conductivity of the atrioventricular node, and the automatism of the Purkinje fibers 3. In this regard, increased action potential duration and ERP. These drugs have a selective antifibrillyatornoe action. here Subgroup 1C - propafenone, flecainide - significantly slow the rate rapid depolarization (phase, slow down the spontaneous slow depolarization (phase and have little effect on repolarization (phase Purkinje fibers. Valium - an analogue of lidocaine, effective when taken orally. Amiodarone (Cordarone) - iodine-containing compound edulcorate in Ceftriaxone Contractions to thyroid hormones). Lidocaine reduces excitability and conductivity (less than quinidine), decreases automaticity, and reduces ERP Purkinje fibers (The ratio of ERP to action potential duration increases). On sinoatrial node lidocaine has no significant influence; on the atrioventricular node has a weak inhibitory effect. In connection with the blockade of Ca2 + channels adrenoceptor amiodarone relaxes and slowed contraction of the heart (reducing the need for cardiac oxygen), and in connection with the blockade aadrenoretseptorov dilates coronary and peripheral vessels, moderately reduces blood pressure. Unlike the drugs of the subgroup IA lidocaine does not increase, and shortens the duration of the action potential of Purkinje fibers. At the same time consider inappropriate long-term introduction of lidocaine for prevention edulcorate arrhythmias in myocardial infarction (Possibly proaritmicheskoe effect of lidocaine, a weakening heartbeat, impaired edulcorate conduction). Side effects blockers: heart failure, bradycardia, impaired atrioventricular conduction, fatigue, toning bronchi (contraindicated in bronchial asthma), peripheral vasoconstriction, enhancement of hypoglycemic agents (Elimination of glucagon action of adrenaline). Propafenone has weak radrenoblokiruyuschey activity. Side effects of lidocaine: a moderate depression of atrioventricular conduction (contraindicated in atrioventricular block II-III degree), irritability, dizziness, paresthesia, tremor. The compounds, that selectively block K + channels and increase the duration of the action potential and ERP without affecting the other properties cardiomyocytes - «pure» class III drugs ibutilid and dofetilVD. Used lidocaine only ventricular tachyarrhythmias and extrasystoles. Phenytoin (diphenine) - antiepileptic drugs, which also edulcorate antiarrhythmic properties similar to those of lidocaine. For drugs in this group are amiodarone, sotalol, bretily, ibutilid, dofetilid. Phenytoin is particularly effective in arrhythmias caused by cardiac glycosides. Lidocaine (lidocaine) - a local anesthetic and is both effective antiarrhythmic drug. Using drugs possible arrhythmia torsade de pointes (1,52%). Thus, these agents markedly depress the excitability and conductivity, there is little effect on the duration action potential.